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doi: 10.1038/s41583-022-00564-x 276 TokudaE.FurukawaY

(6) I Ct, Y Sakarya, N Kirichenko, et al (2016) Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction Canadian Journal of Physiology & Pharmacology, 2016 Oct 19, Volume 95 (Issue 2), Pages 206214

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Diarrhea recurs with each dose escalation but diminishes significantly by weeks 8-12 of treatment